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Scientist: Examples: Pharmacokinetics

Consider the following four-compartment model in which the amount in compartment A at t=0 is A0 and the other compartments are initially empty.

Four Compartment Network Diagram

The differential equations that describe this system are as follows:

A'=-kab*A-kad*A

B'=kab*A-kbc*B+kcb*C

C'=-kcd*C-kcb*C+kbc*B

D'=kad*A+kcd*C

The Scientist model file for this network modeling can be found in the Models / Examples folder in the Scientist installation directory and is as follows:

Four Compartment Network Model

We run a simulation with 60 intervals from T = 0 to 120 and then chart the simulated data using the quick chart function.

Four Compartment Network Model Chart